What is Dr. Grandel Epigen Advanced+?
Dr. Grandel Epigen Advanced+ is a luxury active-ingredient ampoule from the Ampoule Excellence line. The line forms the brand’s most concentrated at-home and in-salon treatment tier. This box is the Dr. Grandel Epigen Advanced+ professional size: 12 glass ampoules of 3 ml each.
Each sealed glass ampoule holds 3 ml of a lightweight concentrate. Dr. Grandel built the concentrate around an epigenetic approach to skin aging. In other words, the approach centers on supporting the skin’s own regenerative processes rather than working on the surface alone.
The texture absorbs quickly and leaves skin feeling silky and well-nourished. For this reason, Epigen Advanced+ is a favorite step in Dr. Grandel spa treatments. It is also a favorite as an at-home course between visits.
Key benefits
- Visibly smoother, firmer-looking skin: formulated to reduce the look of lines, wrinkles and expression lines with regular use.
- Support against visible photoaging: sunflower sprout extract helps counter the visible effects of sun exposure. It also helps reduce the look of pigment spots.
- Rejuvenated-looking skin tone: Retin Royal, a well-tolerated retinoid ester, is formulated to even out skin texture for a more youthful appearance.
- Comfortable on skin: squalane closely mirrors the skin’s own lipids, so the formula feels nourishing rather than greasy.
Key ingredients
Hydroxypinacolone Retinoate, known by Dr. Grandel as Retin Royal, is an ester form of retinoic acid. It is formulated to be gentler than classic retinol while still supporting visible cell renewal and smoother-looking skin. Squalane is a lipid of plant origin that resembles the skin’s own oils. It also helps the formula absorb quickly while supporting the skin barrier.
Dr. Grandel also includes Helianthus Annuus (Sunflower) Sprout Extract for its role in supporting the skin’s visible resilience against environmental and light exposure. Finally, Acetyl Hexapeptide-1, a signal peptide, rounds out the formula to help the skin look more resilient over time. Note that the formula contains fragrance.
How to use the Epigen Advanced+ professional size
- Cleanse the skin thoroughly.
- Then tap the tip of the ampoule so the liquid settles to the bottom.
- After that, hold the ampoule facing you with the marked dot at the top. Use an ampoule opener to protect your hands.
- Then break off the tip against the direction of the marked point.
- Pour the concentrate into your palm, portion by portion. Then tap it gently into freshly cleansed skin on the face, neck and décolleté. While doing so, avoid direct skin contact with the break point.
- Finally, follow with your usual Dr. Grandel nourishing cream.
Use ampoules individually or as a course: 2 to 3 times a week for 1 to 4 weeks. The right choice depends on the intensity you want. Because it holds 12 ampoules, this box covers a full month-long program with ampoules to spare. Use the contents of an ampoule immediately after opening. For external use only, avoiding the eye area.
Who the Epigen Advanced+ professional size is for
Dr. Grandel built Epigen Advanced+ for combination, normal and dry skin that is starting to show visible signs of aging. For example, these signs include loss of smoothness, uneven tone or the first fine lines.
This 12-count box suits estheticians stocking a back bar. It also suits committed at-home users who go through ampoules regularly. That is because it lowers the cost of each treatment compared with buying single retail boxes.
Retail size vs. professional size
This listing is the Dr. Grandel Epigen Advanced+ professional size (12 x 3 ml). Dr. Grandel also sells Epigen Advanced+ in a 3 x 3 ml retail box. That box suits anyone who wants to try the concentrate or fit a short course into a single purchase.
Ounce for ounce, however, the 12-count box works out to a meaningfully lower cost per ampoule. That is why estheticians typically keep it on the back bar for client treatments. It is also why regular users buy it to cover a full month’s course in one order.
Full ingredient list (INCI)
Aqua (Water), Neopentyl Glycol Diheptanoate, C12-15 Alkyl Benzoate, Diisopropyl Adipate, Glycerin, Pentylene Glycol, Propylheptyl Caprylate, Maltodextrin, Squalane, Polyglyceryl-6 Laurate, Lauryl Glucoside, Myristyl Glucoside, Acacia Senegal Gum, Xanthan Gum, Sodium Stearoyl Glutamate, Caprylyl Glycol, Hydroxypinacolone Retinoate, Tocopherol, Caprylhydroxamic Acid, Helianthus Annuus (Sunflower) Sprout Extract, Acetyl Hexapeptide-1, Tetramethyl Acetyloctahydronaphthalenes, Limonene, Citrus Limon (Lemon) Peel Oil, Linalool, Linalyl Acetate, Alpha-Isomethyl Ionone, Hydroxycitronellal, Benzyl Salicylate, Juniperus Virginiana Oil, Pinene, Citrus Aurantium Peel Oil, Hexyl Cinnamal, Geraniol, Parfum (Fragrance)
Ingredient list per Dr. Grandel (grandel.com), confirmed against the 3 x 3 ml retail box, which shares the same formula. Formulas can change; always check the list on the package you receive.
