What is Dr. Grandel Hyaluron Advanced+?
Dr. Grandel Hyaluron Advanced+ is a luxury active-ingredient ampoule, and this listing is its professional size. It comes from the Ampoule Excellence line. Within that line, Dr. Grandel built it as an extra-strength moisture and regeneration treatment.
Each sealed glass ampoule holds 3 ml of a lightweight emulsion. It absorbs quickly and leaves the skin feeling refreshed rather than coated.
The brand’s classic Hyaluron ampoule offers moisture on its own. By comparison, Advanced+ adds a phytoglycogen and a liposomally encapsulated calcium. As a result, these additions give the formula an extra measure of regeneration and barrier support alongside its intensive hydration.
Key benefits
- Intensive, multi-depth hydration: a tenfold complex of different-sized hyaluronic acid molecules. Dr. Grandel formulated it to moisturize the skin from the surface down to its deeper layers.
- Support for the skin’s own moisture production: the formula contains a plant-derived phytoglycogen. It is included to help support the skin’s natural synthesis of hyaluron and collagen.
- Strengthened-looking skin barrier: liposomally encapsulated calcium, formulated to support the skin’s barrier function and help guard against dryness.
- Plump, refreshed feel: a lightweight, quickly absorbed emulsion designed to leave skin looking and feeling replenished rather than greasy.
Key ingredients
Sodium Hyaluronate, Hyaluronic Acid and Glycogen together form the tenfold Hyaluron complex Dr. Grandel highlights in this formula. The brand chose this combination in order to hydrate at several molecular weights and skin depths at once.
In addition, Calcium Chloride supplies the liposomally encapsulated calcium. The brand specifically calls out this calcium for its role in supporting skin firmness and enzyme activity. Meanwhile, Hydrogenated Lecithin and Sucrose Palmitate help form the liposomal delivery system that carries these actives into the skin.
Finally, Tocopherol and Tocopheryl Acetate (vitamin E) round out the formula’s supportive profile. The formula contains fragrance.
How to use Dr. Grandel Hyaluron Advanced+
- Cleanse the skin thoroughly.
- Tap the tip of the ampoule so the liquid settles to the bottom.
- Hold the ampoule facing you with the marked dot at the top. When you open it, use an ampoule opener to protect your hands.
- Then break off the tip against the direction of the marked point.
- Pour the concentrate into your palm, portion by portion. Then pat it gently into freshly cleansed skin on the face, neck and décolleté. Avoid direct skin contact with the break point.
- Finally, follow with your usual Dr. Grandel moisturizer.
Use ampoules individually whenever skin needs an extra moisture boost. You can also use them as a course of 2 to 3 times a week for 1 to 4 weeks. Use the contents of an ampoule immediately after opening. For external use only; avoid the eye area.
Who Dr. Grandel Hyaluron Advanced+ is for
Hyaluron Advanced+ suits any skin type looking for a more intensive hydration step than a standard hyaluronic acid ampoule. It especially suits skin that also needs support for barrier strength and resilience.
The 12-count Dr. Grandel Hyaluron Advanced+ professional size suits estheticians stocking a back bar. It also suits regular users who want enough ampoules on hand for an ongoing hydration routine.
Retail size vs. professional size
This listing is the 12 x 3 ml professional size. Dr. Grandel also sells Hyaluron Advanced+ in a smaller 5 x 3 ml retail box. That box suits anyone who wants to try the formula or cover a short course.
Ounce for ounce, the 12-count professional box lowers the cost per ampoule. That is why estheticians typically keep this size on the back bar. It is also why regular users choose it to avoid reordering as often.
Full ingredient list (INCI)
Aqua (Water), C13-15 Alkane, Butyrospermum Parkii (Shea) Oil, Pentylene Glycol, Glycerin, Polyglyceryl-6 Laurate, Myristyl Glucoside, Lauryl Glucoside, Acacia Senegal Gum, 1,2-Hexanediol, Xanthan Gum, Hydrogenated Lecithin, Sucrose Palmitate, Sodium Hyaluronate, Glycogen, Glyceryl Linoleate, Tocopheryl Acetate, Benzotriazolyl Dodecyl p-Cresol, Hyaluronic Acid, Tocopherol, Caprylhydroxamic Acid, Calcium Chloride, Citric Acid, Alcohol, Tris (Tetramethylhydroxypiperidinol) Citrate, Sodium Hydroxide, Potassium Sorbate, Tetramethyl Acetyloctahydronaphthalenes, Linalyl Acetate, Benzyl Alcohol, Terpineol, Pinene, Geranyl Acetate, Carvone, Parfum (Fragrance), CI 42090 (Blue 1), CI 60730 (Ext. Violet 2)
Ingredient list per Dr. Grandel (grandel.com). Formulas can change; always check the list on the package you receive.






