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Nelly De Vuyst Cellular-Matrix Serum – 10ml / 0.33 fl oz

$100.99

Formulated with acmella oleracea extracts, a “muscle relaxant” ingredient, the Cellular-Matrix Serum helps prevent and reduce the appearance of expression lines. Containing a complex of marine elastin and collagen, this serum moisturizes* and helps soften the aspect of superficial wrinkles. The skin is visibly smoother and firmer. An ideal serum to incorporate in an anti-aging skin care regimen or to use daily to prolong the effect of botulinum injection. *Hydration of the upper layers of the epidermis.

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Nelly De Vuyst Cellular-Matrix Serum

Formulated with Acmella oleracea extracts, a muscle relaxant ingredient known as a natural alternative to Botox®, Nelly De Vuyst Matrix-Cellulaire Serum helps prevent and reduce the appearance of expression lines. Containing a complex of marine elastin and collagen, this serum moisturizes and helps soften the aspect of superficial wrinkles. Your skin will be visibly firmer and smoother. This is an ideal serum to incorporate into your healthy aging skincare routine or to use daily to prolong the effect of botulinum injections by about two months.

  • Instantly plumps fine lines and provides a tightening effect.
  • Provides a relaxing effect on deep expression lines. (Botox®-like effect)
  • Relaxes facial features.
  • Enhances cell adhesion and cohesion.
  • Regenerates cutaneous tissues by promoting cell renewal.

Who Will Love It

Ideal for treating expression and superficial wrinkles. Useful to prevent premature aging and to reduce the appearance of expression lines.

Recommended Use

Apply in the morning and/or evening on expression lines and wrinkles prior to applying treatment oils and creams. Massage and tap into skin until absorbed. To increase efficacy, exfoliate regularly with a Nelly De Vuyst Gommage. Ideal before makeup application to provide a soft radiant look.

Excellent with use of the My Skin Buddy or Le Mieux DermaRed.

Refills available here.

For external use only.

Key Ingredients

  • Acmella Oleracea Extract: Natural muscle relaxant, reverses expression lines and wrinkles.
  • Marine Elastin: Provides deep moisturizing and healthy-aging benefits including a reduction in the appearance of wrinkles and increased skin elasticity.
  • Collagen: Improves skin elasticity, reduces wrinkles, and boosts skin hydration.

Water (Aqua), Hydrolized Elastin, Butylene Glycol, Glycerin, Soluble Collagen, Acmella Oleracea Extract, Phenoxyethanol, Benzoic Acid, Dehydroacetic Acid, Alkyl Acrylate Crosspolymer, Triethanolamine.

What reviewers say

On Nelly De Vuyst’s own website, Nelly De Vuyst Cellular-Matrix Serum holds a 5-star average across 3 customer reviews. Reviewers describe a firmer, smoother feel after use, calling it one of their favorite serums in the line. One reviewer, an esthetician, says she sees an incredible difference for both herself and her clients.

Editorial summary of public customer reviews published on nellydevuyst.com. Individual experiences vary and are not a guarantee of results.

What Customers Are Saying

Buyers report noticeable improvements in skin appearance and fine line reduction after using this serum. Users describe the texture as rich and luxurious without heaviness, making it suitable for nighttime routines. Multiple reviewers mention enhanced hydration and a more youthful appearance, with particular praise for results around the eye area. The serum appears to work effectively as part of a broader skincare regimen, with one user noting enhanced results when combined with weekly exfoliation.

I
★★★★★

“I use this as my nighttime finisher and it's become essential to my routine. The texture is rich and luxurious without feeling heavy, and I've noticed real improvement in fine lines and aging signs.”

via independent review site
I
★★★★★

“This serum hydrates my skin better than anything I've tried before, and the fine lines around my eyes have become much less noticeable. The results are even more impressive when I add a weekly exfoliation to my routine.”

via independent review site
I
★★★★★

“This serum really works for me. My skin looks noticeably better overall, and I've had several people mention that I appear younger than before.”

via independent review site

Most Mentioned Benefits

  • Reduces fine lines
  • Rich, luxurious texture
  • Excellent hydration
  • Lightweight despite richness
  • Visible age-defying results

Best For

Best for mature skin looking for a concentrated daily serum. Many reviewers reach for it as a layering step under moisturizer, and most often mention reduces fine lines.

Things to Know Before Buying

  • Results vary by skin type and routine

Review-Based SEO Summary

Based on customer review themes, Nelly De Vuyst Cellular-Matrix Serum is most often researched by shoppers looking for a concentrated daily serum and the benefits reviewers highlight most — reduces fine lines and rich, luxurious texture..

Based on paraphrased themes and quotes from 3 customer reviews across Amazon, Nellydevuyst, Tiktok — independent of organicskincare.com. Compiled June 2026; paraphrased to comply with platform attribution rules. Individual experiences vary.

Nelly De Vuyst Cellular-Matrix Serum is a concentrated daily serum. It's most often chosen for dry or dehydrated skin, with reviewers highlighting reduces fine lines.

Frequently Asked Questions

What is Nelly De Vuyst Cellular-Matrix Serum?

Nelly De Vuyst Cellular-Matrix Serum is a concentrated daily serum. Buyers report noticeable improvements in skin appearance and fine line reduction after using this serum. Users describe the texture as rich and luxurious without heaviness, making it suitable for nighttime routines. Multiple reviewers mention enhanced hydration and a more youthful appearance, with particular praise for results around the eye area. The serum appears to work effectively as part of a broader skincare regimen, with one user noting enhanced results when combined with weekly exfoliation.

Who is Nelly De Vuyst Cellular-Matrix Serum best for?

Best for mature skin looking for a concentrated daily serum. Many reviewers reach for it as a layering step under moisturizer, and most often mention reduces fine lines.

What benefits do reviewers mention for Nelly De Vuyst Cellular-Matrix Serum?

Reviewers most often mention reduces fine lines, rich, luxurious texture, excellent hydration.

How is Nelly De Vuyst Cellular-Matrix Serum typically used?

It's commonly used as a layering step under moisturizer. Follow the directions on the product, and patch-test first if your skin is sensitive.

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